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“Altruistic” use of Primaquine and Plasmodium falciparum malaria in French Guiana

Date du document : 13/09/2017

Date de mise en ligne : 19/05/2018

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Maladies transmissibles Guyane Paludisme Plasmodium falciparum Primaquine

Since 2015, to achieve the goal of eliminating malaria, the World Health Organisation (WHO) recommends systematic treatment of all patients suffering from Plasmodium falciparum malaria by a single dose of Primaquine, alongside artemisinin-based combination therapy (ACT). The HCSP recommends that the same strategy be applied in French Guiana, as already done in neighbouring countries.

It recommends prescription of Primaquine at a dosage of 0.25 mg per kg, adapted to the weight of children over one year old or over 10 kg.
The prescription of of single-dose Primaquine requires:

  • prior screening for anaemia where possible, with deferred use when haemoglobin rates are below 8 g/dL;
  • postponement of prescription when the patient has known G6PD deficiency;
  • systematic provision of information to patients regarding the risk of haemolytic anaemia, its symptoms, and the importance of monitoring;
  • proposal of follow-up appointments.

The HCSP recommends the design of specific measures for gold-washing sites , to avoid development of antimalarial drugs resistance resistance.

It also recommends that epidemiological monitoring of the implementation and impact of such measures be carried out across French Guiana.

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