Since 2015, to achieve the goal of eliminating malaria, the World Health Organisation (WHO) recommends systematic treatment of all patients suffering from Plasmodium falciparum malaria by a single dose of Primaquine, alongside artemisinin-based combination therapy (ACT). The HCSP recommends that the same strategy be applied in French Guiana, as already done in neighbouring countries.

It recommends prescription of Primaquine at a dosage of 0.25 mg per kg, adapted to the weight of children over one year old or over 10 kg.
The prescription of of single-dose Primaquine requires:

• prior screening for anaemia where possible, with deferred use when haemoglobin rates are below 8 g/dL;
• postponement of prescription when the patient has known G6PD deficiency;
• systematic provision of information to patients regarding the risk of haemolytic anaemia, its symptoms, and the importance of monitoring;
• proposal of follow-up appointments.

The HCSP recommends the design of specific measures for gold-washing sites , to avoid development of antimalarial drugs resistance resistance.

It also recommends that epidemiological monitoring of the implementation and impact of such measures be carried out across French Guiana.